10.17632/WJ6BGXXFD4.1
Shao, Zhiyong
Zhiyong
Shao
Glia promote synaptogenesis through an IQGAP PES-7 in C. elegans
Mendeley
2020
Dataset
Micrography
Dong, Xiaohua
Xiaohua
Dong
Han, Jinshu
Jinshu
Han
2020-02-12
10.17632/wj6bgxxfd4
Creative Commons Attribution 4.0 International
Synapses are essential for the function of the nervous system. Glia play an important role in regulating synaptic formation. To address how glia regulate synaptic development, we use cima-1 mutant C. elegans as an in vivo model. In this data set, we provided data that support 1) Rho GTPase CDC-42 and IQGAP PES-7 are required in presynaptic neurons for VCSC glia-induced presynaptic formation; 2) cdc-42 and pes-7 are also required for normal synaptogenesis during postembryonic developmental stages; 3)PES-7 activated by CDC-42 promotes presynaptic formation most likely through regulating F-actin assembly.