TY - DATA T1 - Association between uric acid and pulse wave velocity in hypertensive patients and in the general population: a systematic review and meta-analysis AU - Rebora, Paola AU - Andreano, Anita AU - Triglione, Nicola AU - Piccinelli, Enrico AU - Palazzini, Matteo AU - Occhi, Lucia AU - Grassi, Guido AU - Valsecchi, Maria Grazia AU - Giannattasio, Cristina AU - Maloberti, Alessandro DO - 10.6084/M9.FIGSHARE.11948730 UR - https://tandf.figshare.com/articles/Association_between_uric_acid_and_pulse_wave_velocity_in_hypertensive_patients_and_in_the_general_population_a_systematic_review_and_meta-analysis/11948730 AB - Purpose: The association between serum uric acid (SUA) and pulse wave velocity (PWV), has been extensively evaluated but with some discrepancies in results. A further limitation refers to the fact that only few data were analyzed taking into account the possible effects of gender. The purpose of this study was to estimate the association between SUA and arterial stiffness in general population and hypertensive patients, as a whole population and as divided by gender, by pooling results from existing studies. Materials and methods: Carotid-femoral and brachial-ankle PWV (cf- and ba-PWV) have been analyzed separately and subgroup analyses by gender are reported. Among 692 potentially relevant works, 24 articles were analyzed. Results: Seven studies referred to cf-PWV in the general population with an overall positive association at adjusted analysis for both males and females (beta regression coefficient (ß): 0.07; 95%CI: 0.03; 0.11 and ß: 0.06; 95%CI: 0.03; 0.09, respectively). Twelve studies referred to ba-PWV in the general population with the finding of a positive association at adjusted analysis for females (ß: 0.04; 95% confidence interval (CI): 0.01;0.07), but not for males (ß: 0.13; 95%CI: −0.09; 0.34). In hypertensive patients only four studies evaluated cf-PWV and one ba-PWV with only one study (with cf-PWV) finding positive association. Conclusion: The association between SUA and cf-PWV resulted significant in general population in both males and females while it was only significant for female regarding ba-PWV. Furthermore, the few available studies found no significant relationship between SUA and both cf- and ba-PWV in hypertensive subjects. KW - Medicine KW - Microbiology KW - FOS: Biological sciences KW - FOS: Biological sciences KW - Genetics KW - Molecular Biology KW - Immunology KW - FOS: Clinical medicine KW - FOS: Clinical medicine KW - 69999 Biological Sciences not elsewhere classified KW - 19999 Mathematical Sciences not elsewhere classified KW - FOS: Mathematics KW - FOS: Mathematics KW - Science Policy PY - 2020 PB - Taylor & Francis ER -